徐强

基本简介

徐强，1959年10月生，教授、博士生导师。1982年1月毕业于南京药学院药学系，1989年3月在日本岐阜药科大学获博士学位。主要科研方向：免疫病理学与免疫药理学，分子药理学

主要科研内容：以疾病发生发展的机理研究为先导，阐明其病理过程的分子机理，建立新的药物作用靶点及相应的分子药理学研究体系，为研制具有新作用特点的药物打下基础。主要包括： 1、T细胞免疫应答的分子基础及其选择性药物调控 2、肿瘤转移的分子机理及其抑制药的研究 3、肝炎发病和慢性化进展的机理及新型肝炎治疗药的研究 4、中药方剂的配伍机理研究

出版著作

1、中药现代研究思路与方法，主编严永清，徐强等，化学工业出版社，北京2006年

2、抗炎免疫药理学编委2005年1月第1版，人民卫生出版社，北京（魏伟、李晓辉、张洪泉、吴曙光主编, 徐强编委）

发表论文

1.Mingjian Fei, Xuefeng Wu, Qiang Xu. Astilbin inhibits contact hypersensitivity via negative cytokine regulation distinct from cyclosporin A. J Allergy Clin Immunol 2005; 116: 1350-1356.

2. Xianming Zhang, Jia Chen, Yugui Xia, Qiang Xu. Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-a?and translocating PKC-d. Cancer Chemother Pharmacol 2005; 55: 251-262.

3. Jule Wang, Yang Sun, Yihua Li and Qiang Xu. Aqueous extract from aerial parts of Artemisia vestita, a traditional Tibetan medicine, reduces contact sensitivity in mice by down-regulating the activation, adhesion and metalloproteinase production of T lymphocytes. Int Immunopharmacol 2005, 5: 407-415.

4. Li Zhang, Yang Sun, Ting Chen, Qiang Xu. Selective depletion of glycyrrhizin from Si-Ni-San, a traditional Chinese prescription, blocks its effect on contact sensitivity in mice and recovers adhesion and metalloproteinases production of T lymphocytes. Int Immunopharmacol 2005, 5: 1193-1204.

5. Junping Kou, Boyang Yu, Qiang Xu. Inhibitory effects of ethanol extract from Radix Ophiopogon japonicus on venous thrombosis linked with its endothelium-protective and anti-adhesive activities. Vascular Pharmacol 2005; 43 (3): 157-163.

6. Junping Kou, Yang Sun,Yuwen Lin, Zhihong Cheng, Wei Zheng, Boyang Yu, and Qiang Xu. Anti-inflammatory Activities of Aqueous Extract from Radix Ophiopogon japonicus and Its Two Constituents. Biol Pharm Bull 2005; 28(7): 1234-1238.

7. Feng Qian, Zi-Chao Zhang, Xue-Feng Wu, Yu-Pei Li, Qiang Xu. Interaction between integrin a5 and fibronectin is required for metastasis of B16F10 melanoma cells. Biochem Biophy Res Comm 2005, 333: 1269–1275

8. Xuefeng Wu, Mingjian Fei, Rengeng Shu, Renxiang Tan, Qiang Xu. Fumigaclavine C, an fungal metabolite, improves experimental colitis in mice via downregulating Th1 cytokine production and metrix metalloproteinase activity. Int Immunopharmacol 2005, 5: 1543-1553.

9. Ying Shao, Junyong Zhang, Chao Tu, Chunhui Dai, Qiang Xu, Zijian Guo. Steric effect on the nuclease activity of Cu(II) complexes with aminoquinoline derivatives. J Inorg Biochem 2005; 99: 1490-1496.

10. Xinhui Tang, Jing Gao, Jin Chen, Feng Fang, Yanping Wang, Huan Dou, Qiang Xu, Zhongming Qian. Inhibition of Ursolic acid on calcium-induced mitochondrial permeability transition and release of two proapoptotic proteins. Biochem Biophy Res Comm 2005; 337: 320-324.

11. Xinhui Tang, Jing Gao, Feng Fang, Jin Chen, Lizhi Xu, Xiaoning Zhao, Qiang Xu. Hepatoprotection of Oleanolic acid is related to its inhibition on mitochondrial permeability transition. Am J Chin Med 2005; 33: 627-637.

12. Chao Tu, Xuefeng Wu, Qin Liu, Xiaoyong Wang, Qiang Xu, Zijian Guo. Crystal structure, DNA-binding ability and cytotoxic activity of platinum(II) 2, 2 -dipyridylamine complexes. Inorg Chim Acta 2004; 357:95-102.

13. Xianming Zhang, Shaopeng Huang, Qiang Xu. Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway. Cancer Chemother Pharmacol 2004; 53(1): 82-88.

14. Jianming Guo, Qiang Xu and Ting Chen. Quantitative determination of astilbin in rabbit plasma by liquid chromatography. J Chromatography B 2004; 805: 357-360.

15. Jun Wang, Ying Zhao and Qiang Xu. Astilbin prevents concanavalin A-induced liver injury by reducing TNF-α production and T lymphocyte adhesion. J Pharm Pharmacol 2004; 56: 495-502.

16. Ying Zhao, Junyan Liu, Jun Wang, Lei Wang, Hao Yin, Renxiang Tan and Qiang Xu. Fumigaclavine C improves concanavalin A-induced liver injury in mice mainly via inhibiting TNF-α production and lymphocyte adhesion to extracellular matrices. J Pharm Pharmacol 2004; 56: 775-782.

17. Xiaopeng Wu,? Hu Zeng, Xianming Zhang,? Ying Zhao,? Haibo Sha, Xiaomei Ge, Minyue Zhang, Xiang Gao and Qiang Xu. Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells. Am J Pathol 2004; 164(6): 2039-2054.

18. Chao Tu, Ying Shao, Ning Gan, Qiang Xu and Zijian Guo. Oxidative DNA Strand Scission Induced by a Trinuclear Copper(II) Complex. Inorg Chem 2004; 43: 4761-4766.I

19. Xin-hui Tang, Ling Gao, Jing Gao, Yi-mei Fan, Li-zhi Xu, Xiao-ning Zhao and Qiang Xu. Mechanisms of Hepatoprotection of Terminalia Catappa L. Extract on D-Galactosamine-induced Liver Damage. Am J Chin Med 2004; 32 (4): 509-519.

20. Jing Gao, Xinhui Tang, Huan Dou, Yimei Fan, Xiaoning Zhao and Qiang Xu. Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. J Pharm Pharmacol 2004; 56: 1449-1455.

21. J. Chen, X. M. Zhang and Q. Xu. Involvement of lymphocytes with a Th1 cytokine profile in bone cell damage associated with MMP-9 production in collagen-induced arthritis. Inflamm Res 2004; 53:670-679.

22. Xiaoyong Wang, Jun Lin, Xianming Zhang, Qin Liu, Qiang Xu, Renxiang Tan, Zijian Guo. 5-fluorouracil-cisplatin addcts with potential antitumor activity. J Inorg Biochem 2003；94(1-2): 186-192.

23. Yang Sun, Ting Chen and Qiang Xu. Si-Ni-San, a traditional Chinese prescription, and its drug-pairs suppress contact sensitivity in mice via inhibition of the activity of metalloproteinases and adhesion of T lymphocytes. J Pharm Pharmacol 2003; 55: 839-846.

24. Jieyun Jiang and Qiang Xu. Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant –induced arthritis in rats. J Ethnopharmacol 2003; 85(1): 53-59.

25. Yu Cai, Ting Chen and Qiang Xu. Astilbin suppresses collagen-induced arthritis via causing the dysfunction of lymphocytes. Inflamm Res 2003; 52(8): 334-340.

26. Yu Cai, Ting Chen and Qiang Xu. Astilbin suppresses delayed-type hypersensitivity by inhibiting lymphocyte migration. J Pharm Pharmacol 2003; 55: 691-696.

27. Lin Yuan, Jianguo Geng and Qiang Xu. N-desulfated heparin improves concanavalin A-induced liver injury partly through inhibiting the T lymphocyte adhesion. Inflamm Res 2003; 52(9): 383-389.

28. Xiaoyong Wang, Xianming Zhang, Jun Lin, Jingwen Chen, Qiang Xu and Zijian Guo. DNA-binding property and anti-tumor activity of bismuth (III) complex with 1, 4, 7, 10-tetrakis(2-pyridylmethyl)-1, 4, 7, 10-tetraazacyclododecane. Dalton Trans 2003; 2379-2380.

29. Jieyun Jiang, Chunxiang Zhou and Qiang Xu. Alleviating effects of Si-Ni-San, a traditional Chinese prescription, on experimental liver injury and its mechanisms. Biol Pharm Bull 2003; 26: 1089-1094.

30. Ting Yang, Chao Tu, Junyong Zhang, Liping Lin, Xianming Zhang, Qin Liu, Jian Ding, Qiang Xu, Zijian Guo. Novel Au(III) complexes of Aminoquinoline Derivatives: Crystal Structure, DNA Binding and Cytotoxicity Against Melanoma and Lung Tumor cells. Dalton Trans 2003; 3419-3424.

31. Qiang Xu, Zhaohua Lu and Xianming Zhang. A novel role of alkaline phosphatase in protection from immunological liver injury in mice. Liver 2002; 22(1): 8-14.

32. Qiang Xu, Jingsong Cao and Xianming Zhang. Liver-infiltrating T lymphocytes cause hepatocyte damage by releasing humoral factors via LFA-1/ICAM-1 interaction in the immunological liver injury. Inflamm Res 2002; 51(1): 44-50.

33. Ting Chen, Jian Xin Li, Yu Cai, Qiang Xu. A Flavonol Glycoside from Smilax glabra. Chin Chem Lett 2002; 537-538.

34. Jianli Liu, Ting Chen, Boyang Yu and Qiang Xu. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari inhibits lymphocyte adhesion to extracellular matrix. J Pharm Pharmacol 2002; 54: 959-965.

35. Yeping Sun and Qiang Xu. Aqueous extract from Rhizoma Notopterygii reduces contact sensitivity by inhibiting lymphocyte migration via down-regulating metalloproteinase activity. Pharmcol Res 2002; 46: 333-337.

36. Qiang Xu and Xiao-Chun Chen. CD4 T lymphocytes cause hepatocyte apoptosis by releasing Th1 cytokines in cellular immunological liver injury. Inflamm Res 2002; 51: 444-450.

37. Feihua Wu, Jingsong Cao, Jieyun Jiang, Boyang Yu and Qiang Xu. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari, improves liver injury by dysfunctioning liver-infiltrating lymphocytes. J Pharm Pharmacol 2001; 53: 681-688.

38. Ru Yan and Qiang Xu. Astilbin selectively facilitates the apoptosis of interleukin-2-dependent phytohemagglutinin-activated Jurkat cells. Pharmacol Res 2001; 44: 135-139.

39. Xianming Zhang, Qiang Xu and Ikuo Saiki. Quercetin Inhibits the Invasion and Mobility of Murine Melanoma B16-BL6 Cells through Inducing Apoptosis via Decreasing Bcl-2 Expression. Clin Exp Metastasis 2001; 18(5): 415-421.

40. Xianming Zhang and Qiang Xu. Metastatic Melanoma Cells Escape from Immunosurveillance through a Novel Mechanism – Releasing Nitric Oxide to Induce Dysfunction of Immunocytes. Melanoma Res 2001; 11(6): 559-567.

41. Jianming Guo, Qiang Xu, Ting Chen. Identification of a new metabolite of astilbin in rats. Clin Chem 2007；53: 465-471.

42. Jingwen Chen, Xiaoyong Wang, Ying Shao, Jianhui Zhu, Yangguang Zhu, Yizhi Li, Qiang Xu, Zijian Guo. A trinuclear copper(II) complex of 2,4,6-tris(di-2-pyridylamine)-1,3,5-triazine shows prominent DNA cleavage activity. Inorg Chem 2007; in press.

43. Liang Chen, Ye Yin, Hongwei Yi, Qiang Xu, Ting Chen. Simultaneous quantification of five major bioactive flavonoids in Rhizoma Smilacis Glabrae by high-performance liquid chromatography. J Pharm Biomed Anal 2007; 43: 1715-20.

44. Feng Qian, Yu-pei Li, Xia Sheng, Zichao Zhang, Ran Song, Wei Dong, Shaoxian Cao, Zichun Hua, Qiang Xu. PRL-3-siRNA Inhibits the Metastasis of B16-BL6 Mouse Melanoma Cells in vitro and in vivo. Mol Med 2007; in press.

45. Ling Xu, Ying Zhao, Yu Qin, Qiang Xu. A Novel Model of Acute Liver Injury in Mice Induced by T Cell-Mediated Immune Response to Lactosylated Bovine Serum Albumin. Clin. Exp. Immunol. 2006; 144: 125-133.

46. Yang Sun, Yihua Li, Xingxin Wu, Wei Zheng, Zonghui Guo, Yang Li, Ting Chen, Zichun Hua, Qiang Xu. Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-kappaB pathways. Int J Mol Med 2006; 17(5): 957-62.

47. Sun Y, Liu J, Qian F, Xu Q. Nitric oxide inhibits T cell adhesion and migration by down-regulation of beta1-integrin expression in immunologically liver-injured mice. Int Immunopharmacol 2006; 6(4): 616-26.

48. Gao J, Chen J, Tang X, Pan L, Fang F, Xu L, Zhao X, Xu Q. Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice. J Pharm Pharmacol 2006; 58(2): 227-33.

49. Xinghui Tang, Jing Gao, Yanping Wang, Yimei Fan, Lizhi Xu, Xiaoning Zhao, Qiang Xu, Zhongming Qian. Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria. J. Nutri. Biochem. 2006; 17: 177-182.

50. Zhi-Fang Hao, Qiang Xu, Zhi-Feng Lu, Jian-Xin Li. 5,7-Bis(benzyloxy)-4H-benzopyran-4-one. Acta Cryst 2006; E62: o552-o554.

51. Jia SP, Guo ZH, Hao ZF, Xu Q, Li JX. 8-benzyl-5,7-bis(benzyloxy)-4H-benzopyran-4-one. Acta Cryst 2006; E62: O3448-O3449

52. Jian Li, Jing Chen, ChunShan Gui, Li Zhang, Yu Qin, Qiang Xu, Jian Zhang, Hong Liu, Xu Shen, Hualiang Jiang. Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis and bioassay. Bioorg Med Chem 2006; 14: 2209-2224.

53. Li Zhang, Yi Dong, Yang Sun, Ting Chen and Qiang Xu. Role of four major components in Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. J Pharm Pharmacol 2006; 58: 1257-1264.

54. Xiaoliang Yang, Yang Sun, Qiang Xu*, Zijian Guo*. Synthesis and Immunosuppressive Activity of L-Rhamnopyranosyl Flavonoids. Org Biomol Chem 2006; 4: 2483-2491.

55. Mingjian Fei, Xuefeng Wu, Qiang Xu. Astilbin inhibits contact hypersensitivity via negative cytokine regulation distinct from cyclosporin A. J Allergy Clin Immunol 2005; 116: 1350-1356.

科研项目

1、2003-2006 选择性免疫抑制剂及其作用机制研究（国家自然科学基金重点项目，主持）。

2、2005-2007 落新妇苷类似物的合成、选择性免疫抑制活性及其先导物优化 (国家自然科学基金，主持)

3、2002-2007 SIRS过程中白细胞激活的信号转导网络及其调控机制（973课题，参加）。

4、2002-2004 落新妇苷选择性免疫抑制作用的分子机理研究（江苏省自然科学基金，主持）。

5、2003-2005 SARS流行病学的免疫机制研究专题三（江苏省高校自然科学基金，主持）。

6、2001-2005 类风湿性关节炎新药的开发（横向，主持）。

7、2000-2004 免疫性肝损伤发病及慢性化进展的分子机理及新型肝炎治疗药的基础研究 (主持)

8、2000-2003 落新妇甙及其类似物选择性抑制活化T细胞的作用机理研究 (国家自然科学基金，主持)

9、2000-2002四逆散的药效物质基础与作用机理的研究(国家自然科学基金，主持)

申请专利

1、ZL 200310112694.X